well you wouldnt do the tuning i hope so not long or hard at all. expensive maby for a few HP gains though. the tough part is wiring up the tuner to the ECU harness. lots of wires and you have to get it right or screw somthing up. you jsut have to take your time and dont cheap out when it comes time to have it tuned at a shop.
if your plannin on boosting then i wouldnt worry bout most of that. tonythetiger has a near stock config(strong eveything) motor and runs 400+whp and eye8pussies has a stock longblock at 300(ish)whp. if your goin boost then you should worry more about compression ratio and how strong your intrenals and tranny are then your displacement or valve weight(more important for NA).
having said that, depending on how much boost or power ya want then youll have to figure out what path to take for tuning. piggy back(safcII) would be ok for lower boost/output numbers but highernumbers youd want an EMS.
figure out which path(boost

or NA

) and then go from there. but from my experiance, jsut hold off on the whole tuning thing till you get the parts and are ready to install them because tuning is expensive and if you get one and have it tuned(around 500 +beans) then add a performance part, ya may have to tune all over again.
if you can get in touch with him ya may want to PM tony, he owns a tuning shop and is a master of this type of info.