Have i got a story for you, ...SLUDGE!!!
My friend has a 2001 Toyota Sienna (i know this is Camry forum but i have a Camry and it is the same engine, close enough - ?)with the 1FMZE with 150,000 miles, and she has not maintained it at all. I changed the oil for her and while she drove it home, the engine started smoking like crazy! She freaked, had the car towed, and she had the mechanic talk to me.
He told me the engine oil pressure fluctuated from 60 lb at start up to zero at 3,000 rpm! (He knew about the sludge issue and i think he could tell i knew what he was talking about.)
He said they had to pull the oil pan, clean the sludge, clean the oil pump strainer, and get out all the sludge they could and hopefully the engine would come back to life for a while. He then handed her the phone and i told her she should have them do it because it made sense - the engine was so sludged i could actually see it through the oil filler hole when i changed her oil! the mechanic didnt say but i think the oil change i did knocked the crud loose (i used no additives or engine cleaners, just oil!)
So they took a day to fix it and cost her like $400, which she was very unhappy about, but it was fair. and even though the mechanic told her my changing the oil just brought on the inevitable, she still naturally blames me since it worked "fine" before so i am giving her half of what she spent. she didn't dump me which a lot of women would do, but now she won't let me work on her car anymore (boo hoo

).
I have a 2002 1FMZE V6 - and i change that oil every 2500.