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random misfire points to either air or fuel delivery problem, however I would leave it for later and make focus on P0301, misfire code for cylinder #1.
if new spark plug do not help (NGK Laser Platinum? they are awesome plugs that can last up to 90-120k miles), see if you have any leaks around cylinder #1.
it could be a serious oil leak from valve cover, it could be leaky fuel injector grommet, etc.
random misfire sounds like vacuum leak (air delivery problem) or maybe your fuel injector is dirty on cylinder #1 and causing a misfire.
also get 24oz bottle of Chevron Techron concentrate from autozone or advanc auto and pour it all at once once into the fuel tank. drive the car and see if it improves.
also when was the last time the air filter and fuel filter were replaced?
any chance you could read OBD2 live monitoring for fuel trims, AFR/oxygen sensor output and such? cheapest way to do this is a OBD2 scanner software, interface from ebay and a PC laptop.
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'02 Solara SLE V6 1MZ-FE/A541E Coupe .: Denso/NGK : Akebono SP : Philips 9011 HIR (low+high) : Toshiba HIR2 9012 (fogs) : Magnefine :. @ 131k
'00 Solara SE 5S-FE/A140E Coupe .: NGK : Hawk HPS : Philips XP : RCEng : Magnefine :. @ 82k
4SALE: connectors for Camry Headlight Wiring Harness and ECU
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