Switched to Mobil One synthetic blend high mileage formula on my 4AFE at 133,600 miles. Changed the oil again at 136,150. I'm at 136,500 now, not a drop has leaked out.
Personally, I wouldn't recommend a full synthetic, use one of the "high mileage" synthetic blends that many oil manufacturers have. Last time I changed my oil it came out clear, looked almost new. Another nice thing is the extended change interval, I think it's roughly 7,000 miles on synthetic. I still change mine every 3,000 because I'm neurotic though.