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Sorry but I have a feeling swapping the RX350 motor into the RX300 wont be as easily done as you'd like.
I'm speculating it would actually be easier to swap the RX330 motor into the RX300 since the 330 uses [almost] the same engine (3MZ and 1MZ series), the 330 is just bored out more than the 300.
The RX350 uses a totally new engine with dual VVT-i and a host of changes in its control logic that I dont think will be a direct bolt-on compatible with the RX300. The 350 engine is shared with the current Camry, Avalon, ES350, and RAV4. The IS350 and GS350 uses a variant of this engine with direct injection.
Just my thoughts - I could be wrong but I think like "wonger" said, trading in may be a better choice than taking on this potentially costly project.
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2012 Lexus RX350 Luxury Pkg w/Nav + HUD, ML & PA
2010 Lexus IS250 AWD w/Nav
2007 Lexus ES350 Ultra Luxury w/Nav, ML & PA
2007 Camry XLE V6
2005 Camry XLE V6
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