The only way to really know if it is safe to extend your oil change interval is to send a sample in for testing.
I have sent samples in every so often for most all of my vehicles over the last 10 years just to make sure nothing major is going wrong with the engines.
I do not do it every oil change, but maybe every 3rd or 4th. it costs around $30 dollars but it is worth the peace of mind.
I bought a Toyota 4Runner a couple years ago, the factory OCI is 10k miles. I was skeptical, and did my oil changes at 5k until recently I decided to give the 10k a try just once and send the sample in for testing.
Results were basically, go ahead and do it, the TBN was still 4.4 so lots of additive remaining, no harmful contamination was found and the viscosity was right on the mark.
Now this was a 2012 4Runner with the 4.0 V6 running Toyota brand synthetic 0w20 oil and Purolator filter. At 60k to 70k miles on the clock.
I have not tested the Avalon yet, bought it used at 23k miles, changed the oil to synthetic 5w30 at 25k miles and will change it again at 30k miles. It is at 29k now.
I am still reluctant to actually do the 10k OCIs on the 4Runner, I think I will still do the 5k interval, but it is nice to know for sure that I can go 10k if I wanted to.
I use Blackstone Laboratories for the testing.
http://www.blackstone-labs.com/