Possible, and if one ground is bad there is potential for others to cause problems as well. Could be a multitude of electrical or mechanical problems so start troubleshooting the easy stuff first. Which engine is it? Any aftermarket stuff (stereo, GPS, security, etc.)?

Things to check (explained in more detail further down):

1. Wire - Battery Negative to ground
2. Wire - Engine block to chassis (engine grounds)
3. Wire - Alternator positive to battery positive
4. Wire - Battery to engine bay fuse box
5. Check voltage of battery
6. Check ALL fuses
7. Pull engine codes
8. Other things smarter folks might suggest

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The Big 3
http://www.the12volt.com/installbay/forum_posts.asp~TID~73496~PN~1

1. Battery negative to ground
2. Engine block to chassis (engine ground)
3. Alternator positive to battery positive

Any one of these cables disconnected or corroded (lowering current capacity) can lead to a wide array of apparently random electrical faults involving lights, radio, or EFI systems. Make sure the wires are in good condition (no frays, breaks, or corrosion) and the connection points are clean and to bare metal. I've replaced all my stock grounds with larger 2-4 gauge cable.

Battery negative to ground is essential, in the pickups and 4 runners it comes stock as a fairly thin wire coupled to the passenger side in a pretty serious kink. Rough roads or loose battery tray can cause the wire to bend, fray, and eventually break.

Engine block to chassis is very important as it is the alternator "negative" ground location. Alternator negative is just the case itself, grounds through the block to the chassis on the left (drivers side) wheel arch sheet metal. On the V6 there is also a ground from the backside of the air intake chamber to the firewall.

22re ground locations
http://www.yotatech.com/f116/22re-ground-wire-locations-guide-194413/

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4. Battery to engine bay fuse box
READ THE FOLLOWING THREAD
http://www.yotatech.com/f116/2nd-gen-mystery-electrical-problem-solved-write-up-33526/

Basically the wire that runs from the positive terminal of the battery to the main fuse box in the engine bay is sufficient when brand new to carry enough current for all the systems it services (many) but any deterioration over time leads to a reduction in its capacity and things start to go awry. The entire thread (so read all the posts, not just the first one) above does an excellent job of describing the problems and the fix so i wont go into it any more than to say check the wire and if necessary, replace with larger gauge cable.

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5. Check battery voltage (pretty sure these are correct)
Not running Min 12.5V
Running (no load) ~14.4
Running (under load) >13.8V

Bad battery or alternator could be an issue here. Could pull the Alternator if you really want and get it tested, but I'd hold off until you exclude the other stuff here.

6. Check fuses - engine bay and drivers side kick panel

7. Check for ECU codes - http://lcengineering.com/TechNotes/TechNote12.htm

 

alrighty thanks, will begin troubleshooting. I fixed the freyed ground wire from the battery to the frame rail, battery has a charge I do believe. Also checked all the fuses and they seem to be good. Will try checking everything out shortly.

 

trucks running, wow do i feel like an idiot. The guy that owned the truck before wired in a cb radio to the positive, after undoing some electrical tape i found all the connections heavily corroded. Also the negative terminal was a tad loose. Runs like a dream now. Thanks for your help!

 

My truck did something similar the other day, Hopped in it, went to start it, and nothing, made like a click noise and the voltage meter moved but nothing else just a click. So i wiggled the battery wires, still nothing. So push started the truck. Went up the driveway a little more, shut it of, turned the key and it started right up! Idk it was weird

 

I've a 91 4x4 with the 22re. Had a starting problem, and all it was, was the connection at the starter. Pulled the cables, cleaned and just like new.

 

Right on dude!

Easy wiring wins again!

Baraklee, starter problem most likely worn contacts, 99% sure.
http://www.4crawler.com/4x4/CheapTricks/Starter.shtml
http://www.toyotanation.com/forum/showthread.php?t=357688&highlight=starter+contacts

The smaller wire leading to the starter is a constant issue for me. The plastic housing that protects the connection broke off so i've got to clean the contact about once every 6 months as it corrodes. Should just connect it and cover in epoxy, add an inline connection further up towards the wirewall...