the way I see it is you need to have an end goal with your truck .. My end goal is some day have a long travel suspension equipped rig, possibly a tacoma rear axle for the extra width, e-locker and LSD up front, and 33's or maybe slightly bigger but nothing extreme.. That all lets me stick with stock axles (T100's and Tacomas) which are easy to find, compared to chromo stuff.. I don't need to replace everything every 30 seconds as I'm not going to be racing or taking 10 foot jumps or anything like that .. I just want more travel and a comfortable ride..
Now, if you want a monster truck the best and strongest way to go about it is a solid axle, and possibly 3 and 4 links.. If you want a fully locked, 36" tire, huge lift trail truck a SAS'd truck with 5.29's or 5.71's would be your best bet and you'll still break shit - often - but whenever you do it's easy to fix with aftermarket stuff and you should start reducing breakages when you get everything changed with beefier parts..
Now if you just want to look super big you'll break shit with IFS and if you haven't yet you will and if you doubt that try and really bag your truck and see what happens ... It's harder to break stuff with open diffs btw .. but it's harder to go far with open diffs.
To me with regearing I noticed a massive increase from 4.10's to 4.56's - I didn't have the option to go 4.88's as I don't want to pay for gears, I just bought the diffs from under a V6.. When i find 4.88 diffs kicking around I'll scoop them up but for the time being the 4.56's are just fine with my 22re and 33x12.5's.. A quick, easy, and cheap upgrade from 4.10's is 4.56's from a V6, or if you get lucky, 4.88's from an auto 4runner with the 31" tire package from like 91 and above.. My truck isn't fast by any means but it isn't struggling to go everywhere either.. 4.88's would make it perfect to me but that hasn't been an option yet..