My original front rotors on our '07 XLS were replaced at 135k. Centric Premium and Akebono ceramic pads; fantastic! I now have 8k on this setup, wonderful.
My transmission had to be rebuilt at 80k, that was super fun. Bigger "ports" or whatever helped after the rebuild and I now do an ATF change/update every oil change which helps quite a bit as well (in fact I just did one Sunday night). The transmission is a serious weak point but it depends on the year.
I installed KYB Strut Plus on the car about 1.5 months ago at 139k, new tires went on 1.5 weeks ago at 141k and the combo made a huge difference in the car.
Tires, I went through a few different sets of Michelin's until I realized they were not what they once were but even more expensive. I was burning through a set in 26-28k at $800 a pop. I had Yokohama Avid Ascend on for 41k and they did pretty well, I just installed Sumitomo HTR A/S P02's and I am really impressed with these tires. I've put about 2400 miles on them since installed, 25-85 degree driving, nasty weather (high winds, driving rain, sleet) and they do quite well. They are more quiet than the Ascends though not as sticky as the Ascends (or Michelin's) but at literally half the price, what do I care. I had to do a banzai run from Ohio to Central Florida and back so I got a lot of time to review.
I really need to do spark plugs, it's on the list. This all seems like a lot, this is after years of ownership and 71K+ of driving...
If not for the transmission, this would be one of my favorite cars I've owned... Just my opinion and experience...